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A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
Tu, Chao; Terraube, Virginie; Tam, Amy Sze Pui; Stochaj, Wayne; Fennell, Brian J; Lin, Laura; Stahl, Mark; LaVallie, Edward R; Somers, Will; Finlay, William J J; Mosyak, Lydia; Bard, Joel; Cunningham, Orla.
Affiliation
  • Tu C; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Terraube V; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland.
  • Tam AS; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Stochaj W; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Fennell BJ; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland.
  • Lin L; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Stahl M; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • LaVallie ER; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Somers W; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Finlay WJ; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland.
  • Mosyak L; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and.
  • Bard J; From Global Biotherapeutics Technologies, Pfizer R&D, Cambridge, Massachusetts 02140 and joel.bard@pfizer.com.
  • Cunningham O; Global Biotherapeutics Technologies, Pfizer R&D, Grange Castle Business Park, Dublin D22, Ireland orla.cunningham@pfizer.com.
J Biol Chem ; 291(3): 1267-76, 2016 Jan 15.
Article in En | MEDLINE | ID: mdl-26515064
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Models, Molecular / Chemokine CXCL13 / Single-Chain Antibodies Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2016 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Models, Molecular / Chemokine CXCL13 / Single-Chain Antibodies Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2016 Document type: Article Country of publication: Estados Unidos