Your browser doesn't support javascript.
loading
Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy.
Nudelman, Kelly N H; McDonald, Brenna C; Wang, Yang; Smith, Dori J; West, John D; O'Neill, Darren P; Zanville, Noah R; Champion, Victoria L; Schneider, Bryan P; Saykin, Andrew J.
Affiliation
  • Nudelman KN; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • McDonald BC; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Wang Y; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Smith DJ; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • West JD; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • O'Neill DP; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Zanville NR; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Champion VL; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Schneider BP; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
  • Saykin AJ; Kelly N.H. Nudelman, Brenna C. McDonald, Yang Wang, Dori J. Smith, John D. West, Darren P. O'Neill, Victoria L. Champion, Bryan P. Schneider, and Andrew J. Saykin, Indiana University School of Medicine; Noah R. Zanville and Victoria L. Champion, Indiana University School of Nursing, Indianapolis, IN
J Clin Oncol ; 34(7): 677-83, 2016 Mar 01.
Article in En | MEDLINE | ID: mdl-26527786
PURPOSE: To investigate the longitudinal relationship between chemotherapy-induced peripheral neuropathy (CIPN) symptoms (sx) and brain perfusion changes in patients with breast cancer. Interaction of CIPN-sx perfusion effects with known chemotherapy-associated gray matter density decrease was also assessed to elucidate the relationship between CIPN and previously reported cancer treatment-related brain structural changes. METHODS: Patients with breast cancer treated with (n = 24) or without (n = 23) chemotherapy underwent clinical examination and brain magnetic resonance imaging at the following three time points: before treatment (baseline), 1 month after treatment completion, and 1 year after the 1-month assessment. CIPN-sx were evaluated with the self-reported Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity four-item sensory-specific scale. Perfusion and gray matter density were assessed using voxel-based pulsed arterial spin labeling and morphometric analyses and tested for association with CIPN-sx in the patients who received chemotherapy. RESULTS: Patients who received chemotherapy reported significantly increased CIPN-sx from baseline to 1 month, with partial recovery by 1 year (P < .001). CIPN-sx increase from baseline to 1 month was significantly greater for patients who received chemotherapy compared with those who did not (P = .001). At 1 month, neuroimaging showed that for the group that received chemotherapy, CIPN-sx were positively associated with cerebral perfusion in the right superior frontal gyrus and cingulate gyrus, regions associated with pain processing (P < .001). Longitudinal magnetic resonance imaging analysis in the group receiving chemotherapy indicated that CIPN-sx and associated perfusion changes from baseline to 1 month were also positively correlated with gray matter density change (P < .005). CONCLUSION: Peripheral neuropathy symptoms after systemic chemotherapy for breast cancer are associated with changes in cerebral perfusion and gray matter. The specific mechanisms warrant further investigation given the potential diagnostic and therapeutic implications.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Magnetic Resonance Imaging / Cerebrovascular Circulation / Peripheral Nervous System Diseases / Neurotoxicity Syndromes / Gray Matter Type of study: Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Journal: J Clin Oncol Year: 2016 Document type: Article Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Magnetic Resonance Imaging / Cerebrovascular Circulation / Peripheral Nervous System Diseases / Neurotoxicity Syndromes / Gray Matter Type of study: Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Journal: J Clin Oncol Year: 2016 Document type: Article Country of publication: Estados Unidos