Activating transcription factor 3--an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review).
Mol Med Rep
; 13(1): 9-12, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26548643
ABSTRACT
Coronary heart diseases, particularly acute coronary syndrome, have increased in morbidity and mortality in recent decades. Percutaneous coronary intervention, coronary artery bypass grafting and thrombolytic agents are effective strategies to rescue the infarcted myocardium. In addition to acute myocardial infarction, the resulting myocardial ischemiareperfusion injury (MIRI) leads to serious secondary injury of the heart. Studies have demonstrated that activating transcription factor (ATF)/cyclic adenosine monophosphate response element binding family member ATF3 had a negative regulatory role in IRI, particularly in the kidney, cerebrum and liver. The present review expounded the expression characteristics of ATF3 and its protective effects against MIRI, providing a theoretical basis for the overexpression of ATF3 in the myocardium as a promising gene-therapeutic strategy for MIRI.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myocardial Reperfusion Injury
/
Activating Transcription Factor 3
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Med Rep
Year:
2016
Document type:
Article