Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study.
Aliment Pharmacol Ther
; 43(2): 252-61, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26549003
ABSTRACT
BACKGROUND:
The risk of urinary tract cancers, including kidney and bladder cancers, was increased in transplant recipients receiving thiopurines.AIM:
To assess the risk of urinary tract cancers in patients with inflammatory bowel disease (IBD) receiving thiopurines in the CESAME observational cohort.METHODS:
Between May 2004 and June 2005, 19 486 patients with IBD, 30.1% of whom were receiving thiopurines, were enrolled. Median follow-up was 35 months (IQR 29-40).RESULTS:
Ten and six patients developed respectively kidney and bladder cancer. The incidence rates of urinary tract cancer were 0.48/1000 patient-years in patients receiving thiopurines (95% CI 0.21-0.95), 0.10/1000 patient-years in patients who discontinued thiopurines (95% CI 0.00-0.56) and 0.30/1000 patient-years in patients never treated with thiopurines (95% CI 0.12-0.62) at entry. The standardised incidence ratio of urinary tract cancer was 3.40 (95% CI 1.47-6.71, P = 0.006) in patients receiving thiopurines, 0.64 (95% CI 0.01-3.56, P = 0.92) in patients previously exposed to thiopurines and 1.17 (95% CI 0.47-12.42, P = 0.78) in patients never treated with thiopurines. The multivariate-adjusted hazard ratio (HR) of urinary tract cancer between patients receiving thiopurines and those not receiving thiopurines was 2.82 (95% CI 1.04-7.68, P = 0.04). Other significant risk factors were male gender (HR 3.98, 95% CI 1.12-14.10, P = 0.03) and increasing age (HR after 65 years (ref <50) 13.26, 95% CI 3.52-50.03, P = 0.0001).CONCLUSION:
Patients with IBD receiving thiopurines have an increased risk of urinary tract cancers. Clinically relevant excess risk is observed in older men.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Inflammatory Bowel Diseases
/
Urologic Neoplasms
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Aliment Pharmacol Ther
Journal subject:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2016
Document type:
Article
Affiliation country:
Francia