BPC 157 antagonized the general anaesthetic potency of thiopental and reduced prolongation of anaesthesia induced by L-NAME/thiopental combination.
Inflammopharmacology
; 23(6): 329-36, 2015 Dec.
Article
in En
| MEDLINE
| ID: mdl-26563892
ABSTRACT
AIM:
We hypothesized that certain effects of the general anaesthetic thiopental are dependent on NO-related mechanisms, which were consequently counteracted by stable gastric pentadecapeptide BPC 157. MAINMETHODS:
(1) All rats intraperitoneally received thiopental (20, 30, 40, and 50 mg/kg) while medication BPC 157 (10 µg/kg, 10 ng/kg, and 10 pg/kg) was given intraperitoneally at 5 min before thiopental. (2) To determine NO-related mechanisms, all rats received intraperitoneally thiopental 40 mg/kg while BPC 157 (10 µg/kg), L-NAME (10 mg/kg) and L-arginine (30 mg/kg) were applied alone and/or combined. BPC 157 was given at 25 min before thiopental while L-NAME, L-arginine, alone and/or combined, were applied at 20 min before thiopental. KEYFINDINGS:
(1) BPC 157 own effect on thiopental anaesthesia BPC 157 (10 ng/kg and 10 µg/kg) caused a significant antagonism of general anaesthesia produced by thiopental with a parallel shift of the dose-response curve to the right. (2) L-NAME-L-arginine-BPC 157 interrelations L-NAME Thiopental-induced anaesthesia duration was tripled. L-arginine Usual thiopental anaesthesia time was not influenced. Active only when given with L-NAME or BPC 157 potentiating effects of L-NAME were lessened, not abolished; shortening effect of BPC 157 abolished. BPC 157 and L-NAME Potentiating effects of L-NAME were abolished. BPC 157 and L-NAME and L-arginine BPC 157 +L-NAME +L-arginine rats exhibited values close to those in BPC 157 rats.SIGNIFICANCE:
Thiopental general anaesthesia is simultaneously manipulated in both ways with NO system activity modulation, L-NAME (prolongation) and BPC 157 (shortening/counteraction) and L-arginine (interference with L-NAME and BPC 157).Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Thiopental
/
Proteins
/
Anesthetics, General
/
NG-Nitroarginine Methyl Ester
Limits:
Animals
Language:
En
Journal:
Inflammopharmacology
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2015
Document type:
Article
Affiliation country:
Croacia