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Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model.
Gao, Zhi-wei; Zhu, Yun-ting; Yu, Ming-ming; Zan, Bin; Liu, Jia; Zhang, Yi-fan; Chen, Xiao-yan; Li, Xue-ning; Zhong, Da-fang.
Affiliation
  • Gao ZW; Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Zhu YT; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Yu MM; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zan B; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Liu J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zhang YF; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Chen XY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li XN; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zhong DF; Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Acta Pharmacol Sin ; 36(12): 1528-36, 2015 Dec.
Article in En | MEDLINE | ID: mdl-26592518
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase 5 Inhibitors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: China Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase 5 Inhibitors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: China Country of publication: Estados Unidos