[Effect of Serum Uric Acid on Renal Function of Patients with Abnormal Glucose Metabolism].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 46(5): 754-8, 2015 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-26619551
ABSTRACT
OBJECTIVE:
To determine the effect of serum uric acid on renal function of patients with abnormal glucose metabolism.METHODS:
A total of 1 495 people who took physical examinations in West China Hospital of Sichuan University in May 2014 were recruited in this study. Serum nitrogen (BUN), creatinine (SCr), triglycerides (TG), cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and uric acid (SUA) of the participants were detected by an automatic biochemical analyzer. The glomerular filtration rate, (eGFR) was calculated with CKD-EPI. According to hyperuriceima (HUA), the participants were divided into groups with impaired fasting glucose (IFG), diabetes (DM), IFG with hyperuicimia, and DM with hyperuricemia. The participants with normal fasting plasma glucose served as controls. Renal dysfunction was detected using eGFR≤50 mL/(min . 1. 73 m2) and SCr≤1. 7 µg/mL.RESULTS:
About 13. 18% (197/1 495) participants were identified as IFG with HUA male (158)/female (39) ratio =4.05; 4.41% (66/1 495) as DM with HUA male (58)/female (8) ratio = 7. 25. Participants with HUA in the control, IFG and DM groups had higher levels of BUN and SCr and lower levels of eGFR than those without HUA (P<0. 05). HUA was more likely to be associated with serum. lipid in the control and IFG groups (most P<0. 05) than in the DM group (P>0. 05). DM patients without HUA had better renal function and serum lipid levels than those who had HUA in their early stage of abnormal glucose metabolism (IFG with HUA) (P<0. 05). The prevalence of renal dysfunction of IFG patients with HUA was significantly higher than those without HUA, similar to the prevalence of renal dysfunction of DM patients with HIUA (P
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prediabetic State
/
Uric Acid
/
Hyperuricemia
/
Glucose
/
Kidney
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Sichuan Da Xue Xue Bao Yi Xue Ban
Year:
2015
Document type:
Article