A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study.
Osteoporos Int
; 27(4): 1645-1652, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26630974
ABSTRACT
UNLABELLED The present study investigated the risk of incident hip fractures according to serum concentrations of vitamin K1 and 25-hydroxyvitamin D in elderly Norwegians during long-term follow-up. The results showed that the combination of low concentrations of both vitamin D and K1 provides a significant risk factor for hip fractures. INTRODUCTION:
This case-cohort study aims to investigate the associations between serum vitamin K1 and hip fracture and the possible effect of 25-hydroxyvitamin D (25(OH)D) on this association.METHODS:
The source cohort was 21,774 men and women aged 65 to 79 years who attended Norwegian community-based health studies during 1994-2001. Hip fractures were identified through hospital registers during median follow-up of 8.2 years. Vitamins were determined in serum obtained at baseline in all hip fracture cases (n = 1090) and in a randomly selected subcohort (n = 1318). Cox proportional hazards regression with quartiles of serum vitamin K1 as explanatory variable was performed. Analyses were further performed with the following four groups as explanatory variable I vitamin K1 ≥ 0.76 and 25(OH)D ≥ 50 nmol/l, II vitamin K1 ≥ 0.76 and 25(OH)D < 50 nmol/l, III vitamin K1 < 0.76 and 25(OH)D ≥ 50 nmol/l, and IV vitamin K1 < 0.76 and 25(OH)D < 50 nmol/l.RESULTS:
Age- and sex-adjusted analyses revealed an inverse association between quartiles of vitamin K1 and the risk of hip fracture. Further, a 50 % higher risk of hip fracture was observed in subjects with both low vitamin K1 and 25(OH)D compared with subjects with high vitamin K1 and 25(OH)D (HR 1.50, 95 % CI 1.18-1.90). The association remained statistically significant after adjusting for body mass index, smoking, triglycerides, and serum α-tocopherol. No increased risk was observed in the groups low in one vitamin only.CONCLUSION:
Combination of low concentrations of vitamin K1 and 25(OH)D is associated with increased risk of hip fractures.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin K 1
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamin K Deficiency
/
Hip Fractures
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Osteoporos Int
Journal subject:
METABOLISMO
/
ORTOPEDIA
Year:
2016
Document type:
Article
Affiliation country:
Noruega