Retrospective Study of the Predictive Value of Target Now in Systemic Therapy for Metastatic Colorectal and Gastric Carcinomas.
Isr Med Assoc J
; 17(10): 612-5, 2015 Oct.
Article
in En
| MEDLINE
| ID: mdl-26665314
ABSTRACT
BACKGROUND:
Predictive biomarkers for personalized treatment of neoplasms are suggested to be a major advancement in oncology and are increasingly used in clinical practice, albeit based on level II evidence. Target Now (TN) employs immunostaining and RNA expression on tumor samples to identify potentially beneficial or ineffective drugs.OBJECTIVES:
To explore retrospectively the predictive value of TN for patients with colorectal and gastric carcinomas.METHODS:
The study group comprised colorectal and gastric carcinoma patients with TN test reports. We identified chemotherapy regimens given for stage IV disease for which TN reports indicated prediction. Protocols were classified as having clinical benefit (CB; i.e., stable disease or any objective response) or progressive disease, and this was compared with the TN prediction.RESULTS:
Nineteen patients--12 colorectal and 7 gastric carcinomas--met the inclusion criteria. There were 26 evaluable treatment protocols; of 18 with a CB15 were predicted to have a CB while 3 were predicted to have a lack of CB. Of eight protocols that had no CB, seven were predicted to have a CB and one a lack of CB. A chi-square test was non-significant (P = 0.78). An exploratory analysis yielded a positive predictive value of 68% and a sensitivity of 83% for the TN test.CONCLUSIONS:
This study emphasizes the need for larger multi-center studies to validate the TN test before it is adopted into clinical practice.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Colorectal Neoplasms
/
Biomarkers, Tumor
/
Precision Medicine
/
Antineoplastic Agents
Type of study:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Isr Med Assoc J
Journal subject:
MEDICINA
Year:
2015
Document type:
Article