Clinicopathologic features, microvessel density, and immunohistochemical expression of ICAM-1 and VEGF in 15 cases of secondary syphilis with oral manifestations.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 121(3): 274-81, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-26682516
ABSTRACT
BACKGROUND:
Several studies have reported the clinical aspects of oral syphilis, but few papers have considered the involved immunoinflammatory mechanisms.OBJECTIVE:
To analyze the clinicopathologic features and expression of immunoinflammatory and vascular proteins in oral secondary syphilis. STUDYDESIGN:
Fifteen patients with oral secondary syphilis were included; histologic features were analyzed using hematoxylin-eosin-stained histologic slides and immunohistochemical reactions were performed against intercellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and CD34.RESULTS:
Lesions presented as multiple plaques and ulcers mostly located on the tongue, lips, and palate. They were covered by a stratified epithelium of irregular thickness showing exocytosis associated with a subjacent plasma cell infiltrate arranged in perivascular and perineural patterns. ICAM-1 and VEGF were expressed on endothelial cells and leukocytes, and microvessel density was similar on the superficial and deep regions of the connective tissue.CONCLUSIONS:
Expression of immunoinflammatory and vascular proteins was intense, suggesting their participation on the pathogenesis of oral secondary syphilis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Syphilis
/
Intercellular Adhesion Molecule-1
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Vascular Endothelial Growth Factor A
/
Mouth Diseases
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
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Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Oral Surg Oral Med Oral Pathol Oral Radiol
Year:
2016
Document type:
Article