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1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; Del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello.
Affiliation
  • Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Mellini P; Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Spallotta F; Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University , Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  • Carafa V; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. De Crecchio 7, 80138 Naples, Italy.
  • Nebbioso A; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. De Crecchio 7, 80138 Naples, Italy.
  • Polletta L; Department of Experimental Medicine, Sapienza University of Rome , Viale Regina Elena 324, 00161 Rome, Italy.
  • Carnevale I; Department of Experimental Medicine, Sapienza University of Rome , Viale Regina Elena 324, 00161 Rome, Italy.
  • Saladini S; Department of Experimental Medicine, Sapienza University of Rome , Viale Regina Elena 324, 00161 Rome, Italy.
  • Trisciuoglio D; Regina Elena National Cancer Institute , Via Elio Chianesi, 53, 00144 Rome, Italy.
  • Gabellini C; Regina Elena National Cancer Institute , Via Elio Chianesi, 53, 00144 Rome, Italy.
  • Tardugno M; Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Zwergel C; Department of Drug Chemistry and Technologies, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Cencioni C; Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University , Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  • Atlante S; Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University , Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  • Moniot S; Department of Biochemistry, University of Bayreuth ; 95447 Bayreuth, Germany.
  • Steegborn C; Department of Biochemistry, University of Bayreuth ; 95447 Bayreuth, Germany.
  • Budriesi R; Department of Pharmacy and Biotechnology, University of Bologna , Via Zamboni 33, 40126 Bologna, Italy.
  • Tafani M; Department of Experimental Medicine, Sapienza University of Rome , Viale Regina Elena 324, 00161 Rome, Italy.
  • Del Bufalo D; Regina Elena National Cancer Institute , Via Elio Chianesi, 53, 00144 Rome, Italy.
  • Altucci L; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. De Crecchio 7, 80138 Naples, Italy.
  • Gaetano C; Institute of Genetics and Biophysics, IGB, Adriano Buzzati Traverso , Via P. Castellino 111, 80131 Naples, Italy.
  • Mai A; Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University , Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
J Med Chem ; 59(4): 1471-91, 2016 Feb 25.
Article in En | MEDLINE | ID: mdl-26689352
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Wound Healing / Dihydropyridines / AMP-Activated Protein Kinases / Sirtuin 1 / Mitochondria / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Wound Healing / Dihydropyridines / AMP-Activated Protein Kinases / Sirtuin 1 / Mitochondria / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos