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B7-1 Blockade Does Not Improve Post-Transplant Nephrotic Syndrome Caused by Recurrent FSGS.
Delville, Marianne; Baye, Emilie; Durrbach, Antoine; Audard, Vincent; Kofman, Tomek; Braun, Laura; Olagne, Jérôme; Nguyen, Clément; Deschênes, Georges; Moulin, Bruno; Delahousse, Michel; Kesler-Roussey, Gwenaëlle; Beaudreuil, Séverine; Martinez, Frank; Rabant, Marion; Grimbert, Philippe; Gallazzini, Morgan; Terzi, Fabiola; Legendre, Christophe; Canaud, Guillaume.
Affiliation
  • Delville M; Université Paris Descartes, Sorbonne Paris Cité, Service de Biothérapie.
  • Baye E; Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
  • Durrbach A; Service de Néphrologie et Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, Institut National de la Santé et de la Recherche Médicale 1197, Université Paris-Saclay, Le Kremlin Bicêtre, France;
  • Audard V; Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
  • Kofman T; Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
  • Braun L; Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France;
  • Olagne J; Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France; Laboratoire d'Anatomo-Pathologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France;
  • Nguyen C; Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
  • Deschênes G; Service de Néphrologie pédiatrique, Hôpital Robert Debré, Paris, France;
  • Moulin B; Service de Néphrologie et Transplantation, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France;
  • Delahousse M; Service de Néphrologie Transplantation, Hôpital Foch, Suresnes, France; and.
  • Kesler-Roussey G; Service de Néphrologie pédiatrique, Centre Hospitalier Universitaire de Nantes, Nantes, France.
  • Beaudreuil S; Service de Néphrologie et Transplantation, Hôpital Bicêtre, Le Kremlin-Bicêtre, Institut National de la Santé et de la Recherche Médicale 1197, Université Paris-Saclay, Le Kremlin Bicêtre, France;
  • Martinez F; Service de Néphrologie Transplantation Adultes, and.
  • Rabant M; Service d'Anatomie et Cytologie Pathologiques, Hôpital Necker-Enfants Malades, Paris, France;
  • Grimbert P; Groupe Hospitalier Henri Mondor Albert Chenevier, Service de Néphrologie et Transplantation, Université Paris Est Créteil, Creteil, France;
  • Gallazzini M; Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
  • Terzi F; Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades.
  • Legendre C; Université Paris Descartes, Sorbonne Paris Cité, Service de Néphrologie Transplantation Adultes, and.
  • Canaud G; Université Paris Descartes, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U1151, Institut Necker Enfants Malades, Service de Néphrologie Transplantation Adultes, and guillaume.canaud@inserm.fr.
J Am Soc Nephrol ; 27(8): 2520-7, 2016 Aug.
Article in En | MEDLINE | ID: mdl-26701979
ABSTRACT
FSGS is a common glomerular disorder that has a high propensity for recurrence after kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the target of one or several circulating factors that lead to cytoskeleton reorganization and proteinuria. Research on podocytes has identified B7-1 as an important factor in podocyte biology and a new therapeutic target in renal disease. Indeed, in four patients with recurrent FSGS after transplant, treatment with the B7-1 blocker abatacept was associated with proteinuria remission. Here, we prospectively treated nine patients with recurrent FSGS after transplant using either abatacept or belatacept, a B7-1 blocker with higher affinity, and did not induce proteinuria remission. Furthermore, we did not detect B7-1 expression by immunofluorescence in podocytes of biopsy specimens from these or other kidney grafts or podocytes of native kidney biopsy specimens. In conclusion, B7-1 blockade did not induce FSGS remission after transplant in our study.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Glomerulosclerosis, Focal Segmental / Kidney Transplantation / B7-1 Antigen / Abatacept / Immunosuppressive Agents / Nephrotic Syndrome Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2016 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Glomerulosclerosis, Focal Segmental / Kidney Transplantation / B7-1 Antigen / Abatacept / Immunosuppressive Agents / Nephrotic Syndrome Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2016 Document type: Article