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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.
Hayes, Tikvah K; Neel, Nicole F; Hu, Chaoxin; Gautam, Prson; Chenard, Melissa; Long, Brian; Aziz, Meraj; Kassner, Michelle; Bryant, Kirsten L; Pierobon, Mariaelena; Marayati, Raoud; Kher, Swapnil; George, Samuel D; Xu, Mai; Wang-Gillam, Andrea; Samatar, Ahmed A; Maitra, Anirban; Wennerberg, Krister; Petricoin, Emanuel F; Yin, Hongwei H; Nelkin, Barry; Cox, Adrienne D; Yeh, Jen Jen; Der, Channing J.
Affiliation
  • Hayes TK; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Neel NF; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Hu C; Departments of Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Gautam P; Institute for Molecular Medicine Finland, University of Helsinki, 00290 Helsinki, Finland.
  • Chenard M; Merck Research Laboratories, Boston, MA 02115, USA.
  • Long B; Merck Research Laboratories, Boston, MA 02115, USA.
  • Aziz M; Departments of Cancer and Cell Biology, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
  • Kassner M; Departments of Cancer and Cell Biology, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
  • Bryant KL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Pierobon M; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.
  • Marayati R; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kher S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • George SD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Xu M; Divisions of Oncology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA; Division of Medical Oncology, Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
  • Wang-Gillam A; Divisions of Oncology, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA; Division of Medical Oncology, Alvin J. Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
  • Samatar AA; Merck Research Laboratories, Boston, MA 02115, USA.
  • Maitra A; Departments of Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Wennerberg K; Institute for Molecular Medicine Finland, University of Helsinki, 00290 Helsinki, Finland.
  • Petricoin EF; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.
  • Yin HH; Departments of Cancer and Cell Biology, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
  • Nelkin B; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Cox AD; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel H
  • Yeh JJ; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel H
  • Der CJ; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel H
Cancer Cell ; 29(1): 75-89, 2016 Jan 11.
Article in En | MEDLINE | ID: mdl-26725216
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Proto-Oncogene Proteins p21(ras) / Proto-Oncogene Proteins c-myc / MAP Kinase Signaling System / Extracellular Signal-Regulated MAP Kinases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Proto-Oncogene Proteins p21(ras) / Proto-Oncogene Proteins c-myc / MAP Kinase Signaling System / Extracellular Signal-Regulated MAP Kinases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos