Genotoxic effect of tocolytic drug ritodrine in combination with smoking during pregnancy.
J Matern Fetal Neonatal Med
; 29(21): 3496-505, 2016 Nov.
Article
in En
| MEDLINE
| ID: mdl-26742485
ABSTRACT
OBJECTIVE:
Tocolytic drugs are used widely in order to prevent preterm birth. Ritodrine, is the only food and drug administration (FDA) approved drug for tocolytic use. We estimated the cytogenetic effect of ritodrine administered as maternal therapy, alone or in combination with smoking, in women and their neonates.METHODS:
Lymphocyte and fibroblasts cultures were evaluated and three indices were analyzed; sister chromatid exchanges (SCEs), proliferation rate index (PRI) and mitotic index (MI) as well as average generation time (AGT) and population doubling time (PDT). Campothacin (CPT-11) was used as a positive control.RESULTS:
Administration of ritodrine up to a month revealed significant reduction of SCEs/cell in neonates in the presence or absence of the mutagenic agent. A statistical significant increase on SCEs, for mothers and neonates, was noticed in neonate's lymphocytes when tocolytic therapy was over a month. Ritodrine revealed a cytoprotective action against smoking when the two factors were combined, but the synergistic action of ritodrine with smoking increased genotoxicity, cytostaticity and cytotoxicity of neonates after long administration (1-3 months).CONCLUSIONS:
The time-depended genotoxic, cytostatic and cytotoxic action of ritodrine alone or in combination with smoking suggests that its administration should not exceed the time period of a month.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ritodrine
/
Lymphocytes
/
Tocolytic Agents
/
Smoking
/
Premature Birth
/
Fibroblasts
/
Obstetric Labor, Premature
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Matern Fetal Neonatal Med
Journal subject:
OBSTETRICIA
/
PERINATOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Grecia