SYNTHESIS AND BIOLOGICAL EFFICACY OF NOVEL PIPERAZINE ANALOGUES BEARING QUINOLINE AND PYRIDINE MOIETIES.
Bioorg Khim
; 41(5): 619-26, 2015.
Article
in En
| MEDLINE
| ID: mdl-26762101
ABSTRACT
A series of novel piperazine analogues bearing quinolin-8-yloxy-butan--ones/pyridin-2-yloxy-ethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA2) and gastric K+/H(+)-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA2-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H+/K(+)-ATPase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperazines
/
Pyridines
/
Quinolines
/
Enzyme Inhibitors
/
Anti-Inflammatory Agents
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Bioorg Khim
Year:
2015
Document type:
Article