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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.
Charych, Deborah H; Hoch, Ute; Langowski, John L; Lee, Steve R; Addepalli, Murali K; Kirk, Peter B; Sheng, Dawei; Liu, Xiaofeng; Sims, Paul W; VanderVeen, Laurie A; Ali, Cherie F; Chang, Thomas K; Konakova, Marina; Pena, Rhoneil L; Kanhere, Rupesh S; Kirksey, Yolanda M; Ji, Chunmei; Wang, Yujun; Huang, Jicai; Sweeney, Theresa D; Kantak, Seema S; Doberstein, Stephen K.
Affiliation
  • Charych DH; Nektar Therapeutics, San Francisco, California. dcharych@nektar.com.
  • Hoch U; Nektar Therapeutics, San Francisco, California.
  • Langowski JL; Nektar Therapeutics, San Francisco, California.
  • Lee SR; Nektar Therapeutics, San Francisco, California.
  • Addepalli MK; Nektar Therapeutics, San Francisco, California.
  • Kirk PB; Nektar Therapeutics, San Francisco, California.
  • Sheng D; Nektar Therapeutics, San Francisco, California.
  • Liu X; Nektar Therapeutics, San Francisco, California.
  • Sims PW; Nektar Therapeutics, San Francisco, California.
  • VanderVeen LA; Nektar Therapeutics, San Francisco, California.
  • Ali CF; Nektar Therapeutics, San Francisco, California.
  • Chang TK; Nektar Therapeutics, San Francisco, California.
  • Konakova M; Nektar Therapeutics, San Francisco, California.
  • Pena RL; Nektar Therapeutics, San Francisco, California.
  • Kanhere RS; Nektar Therapeutics, San Francisco, California.
  • Kirksey YM; Nektar Therapeutics, San Francisco, California.
  • Ji C; Nektar Therapeutics, San Francisco, California.
  • Wang Y; Nektar Therapeutics, San Francisco, California.
  • Huang J; Nektar Therapeutics, San Francisco, California.
  • Sweeney TD; Nektar Therapeutics, San Francisco, California.
  • Kantak SS; Nektar Therapeutics, San Francisco, California.
  • Doberstein SK; Nektar Therapeutics, San Francisco, California.
Clin Cancer Res ; 22(3): 680-90, 2016 Feb 01.
Article in En | MEDLINE | ID: mdl-26832745
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Recombinant Fusion Proteins / Prodrugs / Receptors, Interleukin-2 / Interleukin-2 / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Recombinant Fusion Proteins / Prodrugs / Receptors, Interleukin-2 / Interleukin-2 / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Document type: Article Country of publication: Estados Unidos