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γ-Lactam alkaloids from the flower buds of daylily.
Matsumoto, Takahiro; Nakamura, Seikou; Nakashima, Souichi; Ohta, Tomoe; Yano, Mamiko; Tsujihata, Junichiro; Tsukioka, Junko; Ogawa, Keiko; Fukaya, Masashi; Yoshikawa, Masayuki; Matsuda, Hisashi.
Affiliation
  • Matsumoto T; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Nakamura S; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Nakashima S; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Ohta T; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Yano M; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Tsujihata J; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Tsukioka J; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Ogawa K; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Fukaya M; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Yoshikawa M; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
  • Matsuda H; Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan. matsuda@mb.kyoto-phu.ac.jp.
J Nat Med ; 70(3): 376-83, 2016 Jul.
Article in En | MEDLINE | ID: mdl-26849229
Four new alkaloids, hemerocallisamines IV-VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV-VI was elucidated by the application of the modified Mosher's method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of Aß42 in vitro. This is the first report about bioactive alkaloids with a γ-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemerocallis / Flowers / Alkaloids / Lactams Limits: Animals Language: En Journal: J Nat Med Journal subject: TERAPIAS COMPLEMENTARES Year: 2016 Document type: Article Affiliation country: Japón Country of publication: Japón
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemerocallis / Flowers / Alkaloids / Lactams Limits: Animals Language: En Journal: J Nat Med Journal subject: TERAPIAS COMPLEMENTARES Year: 2016 Document type: Article Affiliation country: Japón Country of publication: Japón