Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial.
Br J Psychiatry
; 208(4): 366-73, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26892847
ABSTRACT
BACKGROUND:
Mindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied.AIMS:
To investigate whether MBCT with discontinuation of mADM is non-inferior to MBCT+mADM.METHOD:
A multicentre randomised controlled non-inferiority trial (ClinicalTrials.govNCT00928980). Adults with recurrent depression in remission, using mADM for 6 months or longer (n= 249), were randomly allocated to either discontinue (n= 128) or continue (n= 121) mADM after MBCT. The primary outcome was depressive relapse/recurrence within 15 months. A confidence interval approach with a margin of 25% was used to test non-inferiority. Key secondary outcomes were time to relapse/recurrence and depression severity.RESULTS:
The difference in relapse/recurrence rates exceeded the non-inferiority margin and time to relapse/recurrence was significantly shorter after discontinuation of mADM. There were only minor differences in depression severity.CONCLUSIONS:
Our findings suggest an increased risk of relapse/recurrence in patients withdrawing from mADM after MBCT.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognitive Behavioral Therapy
/
Depressive Disorder, Major
/
Mindfulness
/
Antidepressive Agents
Type of study:
Clinical_trials
Limits:
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Br J Psychiatry
Year:
2016
Document type:
Article