[Preventive role of pirenzepine in gastric damage during cytostatic therapy. A controlled randomized double-blind study with placebo]. / Ruolo preventivo della pirenzepina nel danno gastrico in corso di terapia citostatica. Studio in doppio cieco randomizzato controllato con placebo.
Minerva Dietol Gastroenterol
; 35(4): 269-72, 1989.
Article
in It
| MEDLINE
| ID: mdl-2695862
Steroids and cytostatic drugs have an undoubtedly damaging action on the gastroduodenal mucosa. The action of pirenzepine was compared with that of the placebo in preventing the gastroduodenal lesions brought on by antiblastic therapy. Sixty patients were separated into two random group under double blind conditions and received 100 mg/die/os of pirenzepine or equivalent placebo for a continuous period of 12 weeks. Antiblastic drugs were administered at the same time. Final endoscopic control and symptomatological findings showed a statistically significant different in favour of the pirenzepine-treated group as early as the 6th week of treatment. No side-effects attributable to pirenzepine were reported.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Diseases
/
Pirenzepine
/
Antineoplastic Agents
Type of study:
Clinical_trials
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Minerva Dietol Gastroenterol
Year:
1989
Document type:
Article
Country of publication:
Italia