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Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.
Karkhanis, Aneesh; Lam, Hui Yuan; Venkatesan, Gopalakrishnan; Koh, Siew Kwan; Chai, Christina Li Lin; Zhou, Lei; Hong, Yanjun; Kojodjojo, Pipin; Chan, Eric Chun Yong.
Affiliation
  • Karkhanis A; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
  • Lam HY; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
  • Venkatesan G; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
  • Koh SK; Singapore Eye Research Institute, The Academia, 20 College Road Discovery Tower Level 6, Singapore 169856.
  • Chai CL; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
  • Zhou L; Singapore Eye Research Institute, The Academia, 20 College Road Discovery Tower Level 6, Singapore 169856.
  • Hong Y; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
  • Kojodjojo P; Department of Cardiology and Cardiac Electrophysiology, National University Heart Centre, 5 Lower Kent Ridge Road, Singapore 119074.
  • Chan EC; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543. Electronic address: phaccye@nus.edu.sg.
Biochem Pharmacol ; 107: 67-80, 2016 May 01.
Article in En | MEDLINE | ID: mdl-26972388
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Models, Molecular / Cytochrome P-450 Enzyme System / Cytochrome P-450 Enzyme Inhibitors / Amiodarone / Anti-Arrhythmia Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2016 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Models, Molecular / Cytochrome P-450 Enzyme System / Cytochrome P-450 Enzyme Inhibitors / Amiodarone / Anti-Arrhythmia Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2016 Document type: Article Country of publication: Reino Unido