Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications.
J Adolesc Young Adult Oncol
; 5(3): 297-302, 2016 09.
Article
in En
| MEDLINE
| ID: mdl-26974246
ABSTRACT
Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterine Cervical Neoplasms
/
ErbB Receptors
/
Molecular Biology
Type of study:
Guideline
/
Prognostic_studies
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
J Adolesc Young Adult Oncol
Year:
2016
Document type:
Article