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Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications.
McEachron, Troy A; Sender, Leonard S; Zabokrtsky, Keri B; Kaltenecker, Brian; Holmes, W Nathan; Cherni, Irene; Manojlovic, Zarko; Liao, Shu-Yuan; Craig, David W; Carpten, John D; Torno, Lilibeth R.
Affiliation
  • McEachron TA; 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
  • Sender LS; 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
  • Zabokrtsky KB; 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
  • Kaltenecker B; 3 Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine , Orange, California.
  • Holmes WN; 4 Department of Epidemiology, School of Medicine, University of California-Irvine , Orange, California.
  • Cherni I; 5 Department of Pediatrics, School of Medicine, University of California-Irvine , Orange, California.
  • Manojlovic Z; 2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
  • Liao SY; 3 Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine , Orange, California.
  • Craig DW; 6 Marian University Osteopathic Medical School , Indianapolis, Indiana.
  • Carpten JD; 7 Department of Radiology, Children's Hospital of Orange County , Orange, California.
  • Torno LR; 1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
J Adolesc Young Adult Oncol ; 5(3): 297-302, 2016 09.
Article in En | MEDLINE | ID: mdl-26974246
ABSTRACT
Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / ErbB Receptors / Molecular Biology Type of study: Guideline / Prognostic_studies Limits: Adolescent / Female / Humans Language: En Journal: J Adolesc Young Adult Oncol Year: 2016 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / ErbB Receptors / Molecular Biology Type of study: Guideline / Prognostic_studies Limits: Adolescent / Female / Humans Language: En Journal: J Adolesc Young Adult Oncol Year: 2016 Document type: Article