Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
Elife
; 52016 03 14.
Article
in En
| MEDLINE
| ID: mdl-26974347
ABSTRACT
The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated. We reveal that a subset of NTS neurons containing cholecystokinin (CCK(NTS)) is responsive to nutritional state and that their activation reduces appetite and body weight in mice. Cell-specific anterograde tracing revealed that CCK(NTS) neurons provide a distinctive innervation of the paraventricular nucleus of the hypothalamus (PVH), with fibers and varicosities in close apposition to a subset of melanocortin-4 receptor (MC4R(PVH)) cells, which are also responsive to CCK. Optogenetic activation of CCK(NTS) axon terminals within the PVH reveal the satiating function of CCK(NTS) neurons to be mediated by a CCK(NTS)âPVH pathway that also encodes positive valence. These data identify the functional significance of CCK(NTS) neurons and reveal a sufficient and discrete NTS to hypothalamus circuit controlling appetite.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraventricular Hypothalamic Nucleus
/
Appetite
/
Cholecystokinin
/
Solitary Nucleus
/
Neural Pathways
Limits:
Animals
Language:
En
Journal:
Elife
Year:
2016
Document type:
Article
Affiliation country:
Reino Unido