Short communication: The role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis.
J Dairy Sci
; 99(6): 4693-4698, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-27060825
ABSTRACT
Extended spectrum ß-lactamase (ESBL)-positive Escherichia coli is a major etiological organism responsible for bovine mastitis. The autoinducer 2 (AI-2) quorum sensing system is widely present in many species of gram-negative and gram-positive bacteria and has been proposed to be involved in interspecies communication. In E. coli model strains, the functional mechanisms of AI-2 have been well studied; however, in clinical antibiotic-resistant E. coli strains, whether AI-2 affects the expression of antibiotic resistance genes has not been reported. In this study, we report that exogenous AI-2 increased the antibiotic resistance of a clinical E. coli strain isolated from a dairy cow with mastitis by upregulating the expression of TEM-type enzyme in an LsrR (LuxS regulated repressor)-dependent manner.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Gene Expression Regulation, Bacterial
/
Beta-Lactam Resistance
/
Beta-Lactams
/
Escherichia coli
/
Homoserine
/
Lactones
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
J Dairy Sci
Year:
2016
Document type:
Article