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Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).
Engers, Darren W; Blobaum, Anna L; Gogliotti, Rocco D; Cheung, Yiu-Yin; Salovich, James M; Garcia-Barrantes, Pedro M; Daniels, J Scott; Morrison, Ryan; Jones, Carrie K; Soars, Matthew G; Zhuo, Xiaoliang; Hurley, Jeremy; Macor, John E; Bronson, Joanne J; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R.
Affiliation
  • Soars MG; Bristol-Myers Squibb Co., Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Zhuo X; Bristol-Myers Squibb Co., Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Hurley J; Bristol-Myers Squibb Co., Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Macor JE; Bristol-Myers Squibb Co., Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
  • Bronson JJ; Bristol-Myers Squibb Co., Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
ACS Chem Neurosci ; 7(9): 1192-200, 2016 09 21.
Article in En | MEDLINE | ID: mdl-27075300
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Picolinic Acids / Pyrazoles / Pyridines / Receptors, Metabotropic Glutamate / Excitatory Amino Acid Agents Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2016 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Picolinic Acids / Pyrazoles / Pyridines / Receptors, Metabotropic Glutamate / Excitatory Amino Acid Agents Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2016 Document type: Article Country of publication: Estados Unidos