Proteinuria as an independent risk factor for contrast-induced acute kidney injury and mortality in patients with stroke undergoing cerebral angiography.
J Neurointerv Surg
; 9(5): 445-448, 2017 May.
Article
in En
| MEDLINE
| ID: mdl-27106594
ABSTRACT
BACKGROUND:
The correlation between proteinuria and contrast-induced acute kidney injury (CI-AKI) in patients with cerebrovascular disease is still unknown.OBJECTIVE:
To determine whether proteinuria is a risk factor for CI-AKI and death in patients with stroke undergoing cerebral angiography.METHODS:
Data from 2015 patients with stroke undergoing cerebral angiography between January 2009 and December 2013 were retrospectively collected. Clinical parameters were obtained from the hospital's computerized database. All variables were analyzed by univariate analysis and multivariate logistic regression analysis.RESULTS:
CI-AKI was seen in 85 patients (4.2%). After adjustment for potential confounding risk factors, patients with proteinuria had a fivefold higher risk of CI-AKI than patients without proteinuria (OR=5.74; 95% CI 2.23 to 14.83; p<0.001). Other independent risk factors for CI-AKI were estimated glomerular filtration rate <60â mL/min/1.73â m2, anemia, and a high National Institute of Health Stroke Scale score. Proteinuria did not increase in-hospital mortality (OR=1.25; 95% CI 0.49 to 3.17; p=0.639) but did increase 1-year mortality (HR=2.30, 95% CI 1.55 to 3.41, p<0.001).CONCLUSIONS:
Proteinuria is an independent risk factor for CI-AKI and 1-year mortality in patients with stroke undergoing cerebral angiography. More attention should be paid to the development of CI-AKI in patients with stroke with proteinuria.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteinuria
/
Cerebral Angiography
/
Contrast Media
/
Stroke
/
Acute Kidney Injury
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurointerv Surg
Year:
2017
Document type:
Article
Affiliation country:
China