Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.
Biochim Biophys Acta
; 1861(8 Pt A): 730-47, 2016 Aug.
Article
in En
| MEDLINE
| ID: mdl-27108063
ABSTRACT
Dietary fat provides essential nutrients, contributes to energy balance, and regulates blood lipid concentrations. These functions are important to health, but can also become dysregulated and contribute to diseases such as obesity, diabetes, cardiovascular disease, and cancer. Within enterocytes, the digestive products of dietary fat are re-synthesized into triacylglycerol, which is either secreted on chylomicrons or stored within cytoplasmic lipid droplets (CLDs). CLDs were originally thought to be inert stores of neutral lipids, but are now recognized as dynamic organelles that function in multiple cellular processes in addition to lipid metabolism. This review will highlight recent discoveries related to dietary fat absorption with an emphasis on the presence, synthesis, and metabolism of CLDs within this process.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Fats
/
Enterocytes
/
Cytoplasm
/
Lipid Metabolism
/
Lipid Droplets
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochim Biophys Acta
Year:
2016
Document type:
Article
Affiliation country:
Estados Unidos