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Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Jönsson, Peter; Southcombe, Jennifer H; Santos, Ana Mafalda; Huo, Jiandong; Fernandes, Ricardo A; McColl, James; Lever, Melissa; Evans, Edward J; Hudson, Alexander; Chang, Veronica T; Hanke, Tomás; Godkin, Andrew; Dunne, Paul D; Horrocks, Mathew H; Palayret, Matthieu; Screaton, Gavin R; Petersen, Jan; Rossjohn, Jamie; Fugger, Lars; Dushek, Omer; Xu, Xiao-Ning; Davis, Simon J; Klenerman, David.
Affiliation
  • Jönsson P; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; Department of Chemistry, Lund University, SE-22100 Lund, Sweden;
  • Southcombe JH; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom; Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, United Kingdom;
  • Santos AM; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Huo J; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Fernandes RA; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • McColl J; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
  • Lever M; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;
  • Evans EJ; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Hudson A; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Chang VT; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Hanke T; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Godkin A; Department of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;
  • Dunne PD; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
  • Horrocks MH; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
  • Palayret M; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom;
  • Screaton GR; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom;
  • Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia;
  • Rossjohn J; Department of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research C
  • Fugger L; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom; Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford OX3 9DS, Unit
  • Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;
  • Xu XN; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; x.xu@imperial.ac.uk simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk.
  • Davis SJ; MRC Human Immunology Unit, University of Oxford, Oxford OX3 9DS, United Kingdom; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom; x.xu@imperial.ac.uk simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk.
  • Klenerman D; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; x.xu@imperial.ac.uk simon.davis@imm.ox.ac.uk dk10012@cam.ac.uk.
Proc Natl Acad Sci U S A ; 113(20): 5682-7, 2016 May 17.
Article in En | MEDLINE | ID: mdl-27114505
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / HLA-A24 Antigen / HLA-DRB1 Chains Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / HLA-A24 Antigen / HLA-DRB1 Chains Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: Estados Unidos