Transsynaptic Retrograde Degeneration: Clinical Evidence with Homonymous RGCL Loss on OCT.
Klin Monbl Augenheilkd
; 233(4): 396-8, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-27116491
ABSTRACT
BACKGROUND:
Retinal thinning after a retrogeniculate lesion (transsynaptic retrograde degeneration) was first described 50 years ago, but has long been a controversial issue. It is now possible to use OCT for the in vivo measurement of retinal thickness. MATERIAL ANDMETHODS:
This was a retrospective study of patients with homonymous visual field loss, with SD-OCT assessment (RNFL and RGCL measurements) in isolated retrogeniculate lesions, subsequently confirmed by a neuroradiologist.RESULTS:
Nine patients with vascular, inflammatory or tumour brain lesions were included in the study. Homonymous RGCL thinning was found in all patients, and correlated with the visual field defect. No correlation was found with RNFL.CONCLUSIONS:
The homonymous defect of RGCL in patients with retrogeniculate lesions demonstrates the presence of transsynaptic retrograde degeneration. RGCL is a better predictor of visual field defects than RNFL measurement.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retina
/
Retinal Degeneration
/
Retinal Ganglion Cells
/
Retrograde Degeneration
/
Visual Pathways
/
Tomography, Optical Coherence
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Klin Monbl Augenheilkd
Year:
2016
Document type:
Article
Affiliation country:
Suiza