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Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.
Mpeta, Bafokeng; Kampira, Elizabeth; Castel, Sandra; Mpye, Keleabetswe L; Soko, Nyarai D; Wiesner, Lubbe; Smith, Peter; Skelton, Michelle; Lacerda, Miguel; Dandara, Collet.
Affiliation
  • Mpeta B; Division of Human Genetics, Department of Pathology (formerly Clinical Laboratory Sciences) & Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Kampira E; Malawi College of Health Sciences, University of Malawi, Blantyre, Malawi.
  • Castel S; Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Mpye KL; Division of Human Genetics, Department of Pathology (formerly Clinical Laboratory Sciences) & Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Soko ND; Division of Human Genetics, Department of Pathology (formerly Clinical Laboratory Sciences) & Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Wiesner L; Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Smith P; Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Skelton M; Division of Human Genetics, Department of Pathology (formerly Clinical Laboratory Sciences) & Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
  • Lacerda M; Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa.
  • Dandara C; Division of Human Genetics, Department of Pathology (formerly Clinical Laboratory Sciences) & Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Pharmacogenomics ; 17(7): 679-90, 2016 05.
Article in En | MEDLINE | ID: mdl-27142945
ABSTRACT

INTRODUCTION:

Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants in CYP3A4/5, SLCO1B1 and ABCC2 on LPV plasma concentration among African HIV-positive patients. MATERIALS &

METHODS:

Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration determined. RESULTS &

DISCUSSION:

LPV plasma concentrations differed >188-fold (range 0.0206-38.6 µg/ml). Both CYP3A4*22 and SLCO1B1 rs4149056G (c.521C) were not observed in this cohort. CYP3A4*1B, CYP3A5*3, CYP3A5*6 and ABCC2 c.1249G>A which have been associated with LPV plasma concentration, showed no significant association.

CONCLUSION:

These findings highlight the need to include African groups in genomics research to identify variants of pharmacogenomics significance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Anti-HIV Agents / Lopinavir / Pharmacogenomic Variants Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Pharmacogenomics Journal subject: FARMACOLOGIA / GENETICA MEDICA Year: 2016 Document type: Article Affiliation country: Sudáfrica
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Anti-HIV Agents / Lopinavir / Pharmacogenomic Variants Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Pharmacogenomics Journal subject: FARMACOLOGIA / GENETICA MEDICA Year: 2016 Document type: Article Affiliation country: Sudáfrica