Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.
Pharmacogenomics
; 17(7): 679-90, 2016 05.
Article
in En
| MEDLINE
| ID: mdl-27142945
ABSTRACT
INTRODUCTION:
Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants in CYP3A4/5, SLCO1B1 and ABCC2 on LPV plasma concentration among African HIV-positive patients. MATERIALS &METHODS:
Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration determined. RESULTS &DISCUSSION:
LPV plasma concentrations differed >188-fold (range 0.0206-38.6 µg/ml). Both CYP3A4*22 and SLCO1B1 rs4149056G (c.521C) were not observed in this cohort. CYP3A4*1B, CYP3A5*3, CYP3A5*6 and ABCC2 c.1249G>A which have been associated with LPV plasma concentration, showed no significant association.CONCLUSION:
These findings highlight the need to include African groups in genomics research to identify variants of pharmacogenomics significance.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Anti-HIV Agents
/
Lopinavir
/
Pharmacogenomic Variants
Type of study:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pharmacogenomics
Journal subject:
FARMACOLOGIA
/
GENETICA MEDICA
Year:
2016
Document type:
Article
Affiliation country:
Sudáfrica