Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy.

Ramot, Yuval; Rotkopf, Shay; Gabai, Rachel Malka; Zorde Khvalevsky, Elina; Muravnik, Sofia; Marzoli, Gabriela Alejandra; Domb, Abraham J; Shemi, Amotz; Nyska, Abraham

Ramot, Yuval; Rotkopf, Shay; Gabai, Rachel Malka; Zorde Khvalevsky, Elina; Muravnik, Sofia; Marzoli, Gabriela Alejandra; Domb, Abraham J; Shemi, Amotz; Nyska, Abraham.

Affiliation

Ramot Y; Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Rotkopf S; Silenseed Ltd, Modiin, Israel.
Gabai RM; Silenseed Ltd, Modiin, Israel.
Zorde Khvalevsky E; Silenseed Ltd, Modiin, Israel.
Muravnik S; Silenseed Ltd, Modiin, Israel.
Marzoli GA; Toxicology Department, Research Toxicology Centre, Pomezia, Italy.
Domb AJ; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel.
Shemi A; Silenseed Ltd, Modiin, Israel.
Nyska A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Consultant in Toxicologic Pathology, Timrat, Israel anyska@bezeqint.net.

Toxicol Pathol ; 44(6): 856-65, 2016 08.

Article in En | MEDLINE | ID: mdl-27147553

Subject(s)
Key words

KRAS; RNAi; biocompatibility; biodegradability; biodegradable materials; drug release; oligonucleotides; pancreatic cancer; safety studies; siRNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Polyglycolic Acid / Drug Carriers / Lactic Acid / Carcinoma, Pancreatic Ductal / RNA, Small Interfering / Antineoplastic Agents Limits: Animals Language: En Journal: Toxicol Pathol Year: 2016 Document type: Article Affiliation country: Israel Country of publication: Estados Unidos

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