Naphthyridines/pharmacology; Phosphodiesterase Inhibitors/pharmacology; Acute Lung Injury/drug therapy; Acute Lung Injury/immunology; Animals; Antigens; Asthma/drug therapy; Asthma/immunology; Cyclic AMP/metabolism; Cyclic Nucleotide Phosphodiesterases, Type 1/antagonists & inhibitors; Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism; Dogs; Eosinophilia/drug therapy; Eosinophilia/immunology; Female; Gastric Emptying/drug effects; Guinea Pigs; Hypertension, Pulmonary/drug therapy; Hypertension, Pulmonary/physiopathology; Lipopolysaccharides; Lung/drug effects; Lung/metabolism; Lung/pathology; Lung/physiopathology; Male; Naphthyridines/therapeutic use; Ovalbumin; Phosphodiesterase Inhibitors/therapeutic use; Pulmonary Disease, Chronic Obstructive/drug therapy; Pulmonary Disease, Chronic Obstructive/pathology; Rats, Sprague-Dawley; Smoke/adverse effects; Vomiting/chemically induced