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Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors.
Kummar, Shivaani; Chen, Alice; Gutierrez, Martin; Pfister, Thomas D; Wang, Lihua; Redon, Christophe; Bonner, William M; Yutzy, William; Zhang, Yiping; Kinders, Robert J; Ji, Jiuping; Allen, Deborah; Covey, Joseph M; Eiseman, Julie L; Holleran, Julianne L; Beumer, Jan H; Rubinstein, Larry; Collins, Jerry; Tomaszewski, Joseph; Parchment, Ralph; Pommier, Yves; Doroshow, James H.
Affiliation
  • Kummar S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Chen A; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Gutierrez M; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Pfister TD; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Wang L; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Redon C; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Bonner WM; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Yutzy W; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Zhang Y; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Kinders RJ; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Ji J; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Allen D; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Covey JM; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Eiseman JL; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Holleran JL; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Beumer JH; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
  • Rubinstein L; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Collins J; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Tomaszewski J; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA.
  • Parchment R; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Pommier Y; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 31 Center Drive, Room 3A44, Bethesda, MD, 20814, USA. doroshoj@mail.nih.gov.
Cancer Chemother Pharmacol ; 78(1): 73-81, 2016 Jul.
Article in En | MEDLINE | ID: mdl-27169793
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / DNA Topoisomerases, Type I / Benzodioxoles / Topoisomerase I Inhibitors / Isoquinolines / Neoplasms Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Chemother Pharmacol Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / DNA Topoisomerases, Type I / Benzodioxoles / Topoisomerase I Inhibitors / Isoquinolines / Neoplasms Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Chemother Pharmacol Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Alemania