Nature versus nurture: A systematic approach to elucidate gene-environment interactions in the development of myopic refractive errors.
Ophthalmic Genet
; 38(2): 117-121, 2017.
Article
in En
| MEDLINE
| ID: mdl-27232389
ABSTRACT
Myopia is the most common eye disorder and major cause of visual impairment worldwide. As the incidence of myopia continues to rise, the need to further understand the complex roles of molecular and environmental factors controlling variation in refractive error is of increasing importance. Tkatchenko and colleagues applied a systematic approach using a combination of gene set enrichment analysis, genome-wide association studies, and functional analysis of a murine model to identify a myopia susceptibility gene, APLP2. Differential expression of refractive error was associated with time spent reading for those with low frequency variants in this gene. This provides support for the longstanding hypothesis of gene-environment interactions in refractive error development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyloid beta-Protein Precursor
/
Genetic Predisposition to Disease
/
Gene-Environment Interaction
/
Myopia
/
Nerve Tissue Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Ophthalmic Genet
Journal subject:
GENETICA MEDICA
/
OFTALMOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Estados Unidos