Estrogen Receptor-ß and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer.
Crit Rev Oncog
; 20(5-6): 373-90, 2015.
Article
in En
| MEDLINE
| ID: mdl-27279236
ABSTRACT
Triple-negative breast cancers (TNBCs) lack estrogen receptor-α (ERα), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) amplification and account for almost half of all breast cancer deaths. This breast cancer subtype largely affects women who are premenopausal, African-American, or have BRCA1/2 mutations. Women with TNBC are plagued with higher rates of distant metastasis that significantly diminish their overall survival and quality of life. Due to their poor response to chemotherapy, patients with TNBC would significantly benefit from development of new targeted therapeutics. Research suggests that the insulin-like growth factor (IGF) family and estrogen receptor beta-1 (ERß1), due to their roles in metabolism and cellular regulation, might be attractive targets to pursue for TNBC management. Here, we review the current state of the science addressing the roles of ERß1 and the IGF family in TNBC. Further, the potential benefit of metformin treatment in patients with TNBC as well as areas of therapeutic potential in the IGF-ERß1 pathway are highlighted.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Somatomedins
/
Estrogen Receptor beta
/
Molecular Targeted Therapy
/
Triple Negative Breast Neoplasms
/
Antineoplastic Agents
Aspects:
Patient_preference
Limits:
Female
/
Humans
Language:
En
Journal:
Crit Rev Oncog
Journal subject:
NEOPLASIAS
Year:
2015
Document type:
Article
Affiliation country:
Canadá