Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma.
Mol Cell Oncol
; 1(3): e964028, 2014.
Article
in En
| MEDLINE
| ID: mdl-27308351
ABSTRACT
A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state. This finding highlights the connection between cell cycle length and the stem-like tumor state.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Mol Cell Oncol
Year:
2014
Document type:
Article
Affiliation country:
Reino Unido