Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide.
Environ Toxicol Pharmacol
; 45: 158-62, 2016 Jul.
Article
in En
| MEDLINE
| ID: mdl-27310207
ABSTRACT
This study investigated the possible hepatoprotection of punicalagin in rats received cyclophosphamide (20mg/kg/day, i.p., for 7 days). Punicalagin given at two doses, 15 and 30mg/kg/day, p.o., for 7 days, starting the same day of cyclophosphamide administration. Punicalagin significantly and dose-dependently reduced the elevations of serum alanine aminotransferase, and liver nuclear factor-κB p65, tumor necrosis factor-α, interleukin-1ß, malondialdehyde, nitric oxide, Bax/Bcl-2 ratio, inducible nitric oxide synthase, caspases 3 and 9 activities, and prevented the decrease of hepatic total antioxidant capacity. Punicalagin also attenuated the histopathological liver tissue damage, and decreased cyclooxygenase-2 expression in liver of rats received cyclophosphamide in a dose-dependent manner. It was concluded that punicalagin protected rat liver against cyclophosphamide toxicity by inhibiting oxidative/nitrosative stress, inflammation, and apoptosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protective Agents
/
Cyclophosphamide
/
Hydrolyzable Tannins
/
Chemical and Drug Induced Liver Injury
Limits:
Animals
Language:
En
Journal:
Environ Toxicol Pharmacol
Year:
2016
Document type:
Article