The role of nuclear PKMζ in memory maintenance.
Neurobiol Learn Mem
; 135: 50-56, 2016 Nov.
Article
in En
| MEDLINE
| ID: mdl-27321162
ABSTRACT
Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Kinase C
/
Cell Nucleus
/
Gene Expression Regulation
/
CREB-Binding Protein
/
Amnesia
/
Amygdala
/
Memory
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Neurobiol Learn Mem
Journal subject:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Corea del Sur