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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
Hao, Yujun; Samuels, Yardena; Li, Qingling; Krokowski, Dawid; Guan, Bo-Jhih; Wang, Chao; Jin, Zhicheng; Dong, Bohan; Cao, Bo; Feng, Xiujing; Xiang, Min; Xu, Claire; Fink, Stephen; Meropol, Neal J; Xu, Yan; Conlon, Ronald A; Markowitz, Sanford; Kinzler, Kenneth W; Velculescu, Victor E; Brunengraber, Henri; Willis, Joseph E; LaFramboise, Thomas; Hatzoglou, Maria; Zhang, Guo-Fang; Vogelstein, Bert; Wang, Zhenghe.
Affiliation
  • Hao Y; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Samuels Y; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Li Q; Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
  • Krokowski D; Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
  • Guan BJ; Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Wang C; Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Jin Z; Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Dong B; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Cao B; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Feng X; Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Xiang M; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Xu C; Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu 241000, China.
  • Fink S; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Meropol NJ; Department of Pharmacognosy, School of Pharmacy, Third Military Medical University, Chongqing 400038, China.
  • Xu Y; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Conlon RA; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Markowitz S; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Kinzler KW; Department of Pharmacy, Suzhou Health College, Suzhou, Jiangsu 215009, China.
  • Velculescu VE; Hathaway Brown School, 19600 North Park Boulevard, Shaker Heights, Ohio 44122, USA.
  • Brunengraber H; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Willis JE; Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • LaFramboise T; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Hatzoglou M; Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Zhang GF; Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, USA.
  • Vogelstein B; Department of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
  • Wang Z; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Nat Commun ; 7: 11971, 2016 06 20.
Article in En | MEDLINE | ID: mdl-27321283
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenocarcinoma / Gene Expression Regulation, Neoplastic / Class I Phosphatidylinositol 3-Kinases / Glutamine / Mutation Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenocarcinoma / Gene Expression Regulation, Neoplastic / Class I Phosphatidylinositol 3-Kinases / Glutamine / Mutation Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido