Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana.
Phytochemistry
; 130: 262-72, 2016 Oct.
Article
in En
| MEDLINE
| ID: mdl-27358036
ABSTRACT
Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-ß-d-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis first, their spectral data, mainly HR-TOFESIMS, 1D-NMR ((1)H, (13)C, DEPT) and 2D-NMR ((1)H(1)H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oleanolic Acid
/
Saponins
/
Triterpenes
/
Plant Roots
/
Magnoliopsida
/
Cytotoxins
/
Antineoplastic Agents, Phytogenic
Country/Region as subject:
America do sul
/
Bolivia
Language:
En
Journal:
Phytochemistry
Year:
2016
Document type:
Article