The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice.
Cell Rep
; 16(3): 615-21, 2016 07 19.
Article
in En
| MEDLINE
| ID: mdl-27373158
ABSTRACT
An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice. In particular, gain of function of Zfhx3 significantly shortens circadian rhythms and alters the transcriptional activity of an important class of neuropeptides that controls intercellular signaling in the suprachiasmatic nucleus (SCN) of the hypothalamus. The ZFHX3/AT axis revealed an important, largely cell-nonautonomous control of the circadian clock. Here, by studying the recently identified circadian mouse mutant Zfhx3(Sci/+), we identify significant effects on sleep homeostasis, a phenomenon that is outside the canonical circadian clock system and that is modulated by the activity of those neuropeptides at a circuit level. We show that the Zfhx3(Sci/+) mutation accelerates the circadian clock at both the hourly scale (i.e., advancing circadian rhythms) and the seconds-to-minutes scale (i.e., anticipating behavioral responses) in mice. The in vivo results are accompanied by a significant presence of sleep targets among protein-protein interactions of the Zfhx3(Sci/+)-dependent network.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep
/
Circadian Rhythm
/
Homeodomain Proteins
/
Circadian Clocks
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cell Rep
Year:
2016
Document type:
Article
Affiliation country:
Italia