Interferons and inflammasomes: Cooperation and counterregulation in disease.
J Allergy Clin Immunol
; 138(1): 37-46, 2016 07.
Article
in En
| MEDLINE
| ID: mdl-27373324
ABSTRACT
Interferons and the IL-1 family of cytokines have important roles in host defense against invading viruses and bacteria. Inflammasomes, multimeric cytosolic sensors of infection, are required for IL-1ß and IL-18 processing and release. Interferons, IL-1ß, and IL-18 are also implicated in autoimmune disease and chronic inflammation. Although independent but complementary pathways induce these cytokine subsets during infection, in some circumstances the cross-talk between these key inflammatory mediators is a particular requirement for effective host defense. In this review we will summarize recent discoveries concerning the potentiation of inflammasome responses by type I interferons, particularly in patients with gram-negative bacterial infections, and reflect on the molecular mechanisms of IFN-ß's immunosuppressive effects through modulation of inflammasome and IL-1ß signaling in patients with tuberculosis and multiple sclerosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interferons
/
Inflammasomes
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Allergy Clin Immunol
Year:
2016
Document type:
Article
Affiliation country:
Alemania