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The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease.
Zhang, Jun; Wang, Xianyun; Li, Jing; Huang, Rui; Yu, Xuerui; Dong, Ci; Liu, Pujuan; Zhang, Fan; Hu, Jie; Qi, Yixin; Zhang, Jing; Li, Quanhai; Yan, Baoyong.
Affiliation
  • Zhang J; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Wang X; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Li J; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
  • Huang R; Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Yu X; Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Dong C; Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Liu P; Department of Cardiac Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Zhang F; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Hu J; School of Nursing, Hebei Medical University, Shijiazhuang, Hebei, China.
  • Qi Y; Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Zhang J; Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
  • Li Q; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
  • Yan B; Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
Biomed Res Int ; 2016: 5683097, 2016.
Article in En | MEDLINE | ID: mdl-27379248
ABSTRACT
Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Brain / Stem Cell Transplantation / Disease Models, Animal / Stem Cell Research Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomed Res Int Year: 2016 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Brain / Stem Cell Transplantation / Disease Models, Animal / Stem Cell Research Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomed Res Int Year: 2016 Document type: Article Affiliation country: China