Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings.
Clin Pharmacol Ther
; 46(1): 78-81, 1989 Jul.
Article
in En
| MEDLINE
| ID: mdl-2743709
ABSTRACT
The pharmacokinetics of a single oral dose of 6 mg perphenazine was studied in a group of six slow and six rapid hydroxylators of debrisoquin. Peak serum concentrations of perphenazine were significantly higher in slow hydroxylators than they were in rapid hydroxylators (2.4 +/- 0.6 versus 0.7 +/- 0.3 nmol/L, p less than 0.001). The AUC(0-12) was also higher in slow hydroxylators than it was in rapid hydroxylators (18.5 +/- 6.2 versus 4.5 +/- 2.5 nmol.L-1.hr, p less than 0.001). The data suggest that the disposition of the antipsychotic drug perphenazine covaries with polymorphic debrisoquin hydroxylation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Perphenazine
/
Debrisoquin
/
Isoquinolines
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Pharmacol Ther
Year:
1989
Document type:
Article
Affiliation country:
Suecia