Cost-effectiveness study of the microbiological diagnosis of tuberculosis using geneXpert MTB/RIF®. / Estudio de coste-efectividad del diagnóstico microbiológico de tuberculosis mediante geneXpert MTB/RIF®.
Enferm Infecc Microbiol Clin
; 35(7): 403-410, 2017.
Article
in En, Es
| MEDLINE
| ID: mdl-27445177
ABSTRACT
INTRODUCTION/OBJECTIVE:
To perform a cost-effectiveness analysis of a molecular biology technique for the diagnosis of tuberculosis compared to the classical diagnostic alternative.METHODS:
A cost-effectiveness analysis was performed to evaluate the theoretical implementation of a molecular biology method including two alternative techniques for early detection of Mycobacterium tuberculosis Complex, and resistance to rifampicin (alternative1 one determination in selected patients; alternative2 two determinations in all the patients). Both alternatives were compared with the usual procedure for microbiological diagnosis of tuberculosis (staining and microbiological culture), and was accomplished on 1,972 patients in the period in 2008-2012. The effectiveness was measured in QALYs, and the uncertainty was assessed by univariate, multivariate and probabilistic analysis of sensitivity.RESULTS:
A value of 8,588/QALYs was obtained by the usual method. Total expenditure with the alternative1 was 8,487/QALYs, whereas with alternative2, the cost-effectiveness ratio amounted to 2,960/QALYs. Greater diagnostic efficiency was observed by applying the alternative2, reaching a 75% reduction in the number of days that a patient with tuberculosis remains without an adequate treatment, and a 70% reduction in the number of days that a patient without tuberculosis remains in hospital.CONCLUSION:
The implementation of a molecular microbiological technique in the diagnosis of tuberculosis is extremely cost-effective compared to the usual method. Its introduction into the routine diagnostic procedure could lead to an improvement in quality care for patients, given that it would avoid both unnecessary hospitalisations and treatments, and reflected in economic savings to the hospital.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rifampin
/
Tuberculosis, Pulmonary
/
Bacteriological Techniques
/
Cost-Benefit Analysis
/
Tuberculosis, Multidrug-Resistant
/
Nucleic Acid Amplification Techniques
/
Antibiotics, Antitubercular
/
Mycobacterium tuberculosis
Type of study:
Diagnostic_studies
/
Health_economic_evaluation
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
Language:
En
/
Es
Journal:
Enferm Infecc Microbiol Clin
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2017
Document type:
Article