Emergence of Mycoplasma genitalium strains showing mutations associated with macrolide and fluoroquinolone resistance in the region Dresden, Germany.

Dumke, Roger; Thürmer, Alexander; Jacobs, Enno

Dumke, Roger; Thürmer, Alexander; Jacobs, Enno.

Affiliation

Dumke R; TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany. Electronic address: roger.dumke@tu-dresden.de.
Thürmer A; TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany.
Jacobs E; TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany.

Diagn Microbiol Infect Dis ; 86(2): 221-3, 2016 Oct.

Article in En | MEDLINE | ID: mdl-27448452

ABSTRACT

ABSTRACT

Among 323 specimens from male patients with symptoms of non-gonococcal urethritis, Mycoplasma genitalium was detected in 19 samples by real-time PCR. Mutations of 23S rRNA gene associated with macrolide resistance were confirmed in 10 strains. Amino acid changes at positions 81 and 83 of ParC protein were demonstrated indicating quinolone resistance of two strains.

Subject(s)
Key words

23S rRNA mutation; Genotyping; Macrolide resistance; Mycoplasma genitalium; Quinolone resistance; Topoisomerase mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrolides / Fluoroquinolones / Drug Resistance, Bacterial / Mycoplasma genitalium / Anti-Bacterial Agents / Mutation Type of study: Risk_factors_studies Limits: Humans / Male Country/Region as subject: Europa Language: En Journal: Diagn Microbiol Infect Dis Year: 2016 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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