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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito, Yasushi; Ofengeim, Dimitry; Najafov, Ayaz; Das, Sudeshna; Saberi, Shahram; Li, Ying; Hitomi, Junichi; Zhu, Hong; Chen, Hongbo; Mayo, Lior; Geng, Jiefei; Amin, Palak; DeWitt, Judy Park; Mookhtiar, Adnan Kasim; Florez, Marcus; Ouchida, Amanda Tomie; Fan, Jian-bing; Pasparakis, Manolis; Kelliher, Michelle A; Ravits, John; Yuan, Junying.
Affiliation
  • Ito Y; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Ofengeim D; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Najafov A; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Das S; MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Cambridge, MA 02139, USA.
  • Saberi S; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. ALS Translational Research Program, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Li Y; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 QiuYue Road, PuDong District, Shanghai, 201210, China.
  • Hitomi J; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Zhu H; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Chen H; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Mayo L; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Geng J; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Amin P; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • DeWitt JP; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Mookhtiar AK; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Florez M; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Ouchida AT; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  • Fan JB; Illumina, Inc., San Diego, CA 92122, USA.
  • Pasparakis M; Institute for Genetics, University of Cologne, 50674 Cologne, Germany.
  • Kelliher MA; Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Ravits J; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. ALS Translational Research Program, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Yuan J; Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 QiuYue Road, PuDong District, Shanghai, 201210, China. jyuan@hms.harvar
Science ; 353(6299): 603-8, 2016 Aug 05.
Article in En | MEDLINE | ID: mdl-27493188
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Apoptosis / Transcription Factor TFIIIA / Receptor-Interacting Protein Serine-Threonine Kinases / Amyotrophic Lateral Sclerosis / Nerve Degeneration Limits: Animals / Humans Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axons / Apoptosis / Transcription Factor TFIIIA / Receptor-Interacting Protein Serine-Threonine Kinases / Amyotrophic Lateral Sclerosis / Nerve Degeneration Limits: Animals / Humans Language: En Journal: Science Year: 2016 Document type: Article Affiliation country: Estados Unidos