Atomoxetine ameliorates nocturnal enuresis with subclinical attention-deficit/hyperactivity disorder.
Pediatr Int
; 59(2): 181-184, 2017 Feb.
Article
in En
| MEDLINE
| ID: mdl-27501068
ABSTRACT
BACKGROUND:
Recent studies have shown that incontinence and attention-deficit/hyperactivity disorder (ADHD) coexist and there is an interaction between them. The treatment for nocturnal enuresis (NE) and ADHD, however, has not been established.METHODS:
At the first visit to the outpatient clinic, physical examination and history taking were carried out in 265 new patients with NE. After excluding the possibility of comorbid ADHD and related disorders, patients with monosymptomatic NE (MNE) were treated with desmopressin and/or alarm, and those with non-monosymptomatic NE (NMNE) were treated with anti-cholinergics and/or alarm. This 12 week treatment did not work in 65 patients, and they were re-assessed for comorbid ADHD. A total of 24 were diagnosed with ADHD, and they were treated with atomoxetine (1.8 mg/kg/day) in addition to ongoing therapy for NE.RESULTS:
After 8 weeks of atomoxetine, the average wet nights per months was significantly decreased 18.5-4.6 in the MNE group (P = 0.001), and 22.1-12.4 in the NMNE group (P = 0.0251). Overall, atomoxetine was beneficial in 19 of 24 patients.CONCLUSIONS:
Atomoxetine may be a suitable option for refractory NE with comorbid ADHD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Adrenergic Uptake Inhibitors
/
Nocturnal Enuresis
/
Atomoxetine Hydrochloride
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pediatr Int
Journal subject:
PEDIATRIA
Year:
2017
Document type:
Article
Affiliation country:
Japón
Publication country:
AU
/
AUSTRALIA
/
AUSTRÁLIA