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Placental control of drug delivery.
Al-Enazy, Sanaalarab; Ali, Shariq; Albekairi, Norah; El-Tawil, Marwa; Rytting, Erik.
Affiliation
  • Al-Enazy S; Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Ali S; Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Albekairi N; Department of Pharmacology & Toxicology, King Saud University, Riyadh, Saudi Arabia.
  • El-Tawil M; Department of Pharmacology, Tanta University, Tanta, Egypt.
  • Rytting E; Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: erik.rytting@utmb.edu.
Adv Drug Deliv Rev ; 116: 63-72, 2017 07 01.
Article in En | MEDLINE | ID: mdl-27527665
ABSTRACT
The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream-whether from environmental contact, occupational exposure, medication, or drug abuse-the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placenta / Pharmaceutical Preparations / Maternal-Fetal Exchange Limits: Female / Humans / Pregnancy Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placenta / Pharmaceutical Preparations / Maternal-Fetal Exchange Limits: Female / Humans / Pregnancy Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Affiliation country: Estados Unidos