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A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.
Cuadrado-Tejedor, Mar; Garcia-Barroso, Carolina; Sánchez-Arias, Juan A; Rabal, Obdulia; Pérez-González, Marta; Mederos, Sara; Ugarte, Ana; Franco, Rafael; Segura, Victor; Perea, Gertrudis; Oyarzabal, Julen; Garcia-Osta, Ana.
Affiliation
  • Cuadrado-Tejedor M; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Garcia-Barroso C; Anatomy Department, School of Medicine, University of Navarra, Pamplona, Spain.
  • Sánchez-Arias JA; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Rabal O; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Pérez-González M; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Mederos S; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Ugarte A; Cajal Institute, CSIC, Madrid, Spain.
  • Franco R; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Segura V; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Perea G; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain.
  • Oyarzabal J; Bioinformatics Unit, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Garcia-Osta A; Cajal Institute, CSIC, Madrid, Spain.
Neuropsychopharmacology ; 42(2): 524-539, 2017 01.
Article in En | MEDLINE | ID: mdl-27550730
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidinones / Histone Deacetylase Inhibitors / Phosphodiesterase 5 Inhibitors / Alzheimer Disease / Hippocampus / Neuronal Plasticity Limits: Animals Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2017 Document type: Article Affiliation country: España Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidinones / Histone Deacetylase Inhibitors / Phosphodiesterase 5 Inhibitors / Alzheimer Disease / Hippocampus / Neuronal Plasticity Limits: Animals Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2017 Document type: Article Affiliation country: España Country of publication: Reino Unido