Neutrophils and the inflammatory tissue microenvironment in the mucosa.
Immunol Rev
; 273(1): 112-20, 2016 09.
Article
in En
| MEDLINE
| ID: mdl-27558331
ABSTRACT
The interaction of neutrophils (PMNs) and epithelial cells are requisite lines of communication during mucosal inflammatory responses. Consequences of such interactions often determine endpoint organ function, and for this reason, much interest has developed around defining the constituents of the tissue microenvironment of inflammatory lesions. Physiologic in vitro and in vivo models have aided in the discovery of components that define the basic inflammatory machinery that mold the inflammatory tissue microenvironment. Here, we will review the recent literature related to the contribution of PMNs to molding of the tissue microenvironment, with an emphasis on the gastrointestinal (GI) tract. We focus on endogenous pathways for promoting tissue homeostasis and the molecular determinants of neutrophil-epithelial cell interactions during ongoing inflammation. These recent studies highlight the dynamic nature of these pathways and lend insight into the complexity of treating mucosal inflammation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Epithelial Cells
/
Cellular Microenvironment
/
Inflammation
/
Intestinal Mucosa
/
Neutrophils
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Immunol Rev
Year:
2016
Document type:
Article
Affiliation country:
Estados Unidos